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  • 東北大学大学院医工学研究科人工臓器医工学講座 同大学院医学系研究科内科学専攻心臓病電子医学 - [The name of this laboratory is Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer (IDAC), Tohoku University. Artificial Heart Research Program in Tohoku Univ. were performed in this department. Deterministic chaos & fractal theory concerning medical field were also studied in this department, especially in the field of Cardiology. Clinical studies of the interventional therapy and ultrasonic cardiology were performed in the various hospitals in this prefecture.][* [[東北大学で実験を重ねてきた植込み型補助人工心臓:EVAHEART 小型コントローラ C02システムの販売が開始されました。|http://mec1.idac.tohoku.ac.jp/?%BF%B7%A4%B7%A4%A4%BE%AE%B7%BF%BF%CD%B9%A9%BF%B4%C2%A1%A5%B3%A5%F3%A5%C8%A5%ED%A1%BC%A5%E9]]]
  • Welcome Professor Yambe's Home Page!! - [Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University, and Tohoku University Hospital][上の写真は当教室で開発した空気圧駆動型の[[完全置換型人工心臓|Pneumatic driven Total Artificial Heart]]で、まだ私の手作りなのでで製品化へ向けてはまだ全然これからですが、塩化ビニルのサック内面をポリウレタンでコーティングし、コネクター内蔵のシリコンボール弁で耐久性の向上を目指しています。この心臓は山羊の急性実験でのfitting studyまでは何とか進んだ所で、もう少しrefineして慢性実験に持っていきたいところです。]
  • 履歴書 - [Assistant professor, Institute of Development, Aging and Cancer, ][# Inventor, European Patent; Artificial myocardial device assisting motion of heart,Applicants No04711685.0-2310, OCT/JP2004001695]
  • archives - [Yambe T, Shibata M, Seki T, Miura H, Takashima M, Sugita N, Shiraishi Y and Yoshizawa M.Pulse Diagnosis Machine Developed for the Electric Doctor Bag for the Disaster shelter in Sendai Quake.HUMAN SCIENCE & TECHNOLOGY, vol.10,2012, pp.6-12, apr. 2013][Yambe T. et al. Sympathetic Nerve Adjustment to Artificial Circulation,Heart Replacement-Artificial Heart6,pp.308-312,1998 {{attach_anchor_string(PDF,SNAAC.pdf)}}]
  • Welcome Dr. Yambe's Home Page!! (eng) - [Institute of Development, Aging anc Cancer, Tohoku University][Atherosclerosis, Cardiology, Artificial heart]
  • helical flow TAHと、commercial available pumpによる TAH - (matched in keyword)(matched in keyword)
  • 論文・出版リスト - 山家先生分 - [# Yambe T, Nitta S, Katahira Y, Sonobe T, Naganuma S, Akiho H, Hayashi H, Tanaka M, Miura M, Sato N, Mohri H, Yoshizawa M, and Takeda H: Development of the total artificial heart control system. Sci Rep Res Inst Tohoku Univ [Med].38(1):29-34. 1991][# Yambe T, Nitta S, Katahira Y, Sonobe T, Naganuma S, Akiho H, Hayashi H, Tanaka M, Miura M, Sato N, Mohri H, Yoshizawa M, and Takeda H: Postganglionic sympathetic nerve activity with correlation to heart rhythm during left ventricular assistance. Artif Organs15: 212-7. 1991]
  • special lecture - [# Invited lecture for the Interim report meeting for external evaluation of the Project: The comprehensive basic research on the development of Japanese original implantable total artificial heart"Development of the Vibrating flow pump & automatic control algorithm for an artificial heart by the use of Chaos theory" March13, 2000][# Invited lecture for IIAS International workshop on orders and structures in complex systems "Artificial heart and complex systems" July 29,1997.]
  • Masaryk University - [Institute of Development, Aging and Cancer (IDAC) concluded Academic exchange with Masalyk University School of Medicine. ][There was tradition in industrial technology, in the animal experiment of an artificial heart which was globally prosperous those days, the world record was begun to beat repeatedly and the medical world in the world was surprised. ]
  • Origin of Chaos - [The clinical significance of the chaotic dynamics in the cardiovascular system had attracted attention. Circulation system is a kind of "complex system" having many feedback circuits. So, it was very difficult to investigate the origin of chaos in the circulatory system. In this study, we investigated the origin of chaos by the use of the methodology of the open loop analysis with an artificial heart, which did not have any fluctuation in their own pumping rate and contraction power, in the chronic animal experiments using healthy adult goats. As a result, in the circulatory time series data of the artificial heart, which did not have any fluctuation, low dimensional deterministic chaos was discovered by the methodology of nonlinear mathematical analyzing technique, suggesting the importance of the blood vessel system in the chaotic dynamics of the cardiovascular system. To investigate the origin of chaos furthermore, sympathetic nerve activity was directly measured in the animal experiments with artificial heart circulation. Chaotic dynamics was also recognized in the sympathetic nerve action potentials, even during artificial heart circulation, suggesting the importance of a central nervous system. In the next step, in order to generate the chaotic dynamics in circulation, electrical simulation model of a left heart circulation with a feed back loop with some delay were tested and we found that we can make chaos in circulation by the feedback loop. Thus, we had constitute the artificial baroreflex system with an artificial heart system and found that we can make chaos in animal model. And finally we proposed the clinical application of these methodology for the diagnosis of an autonomic nervous system and found that it may be useful. These findings may be useful for analyzing the nonlinear dynamics in circulation.][The clinical significance of the chaotic dynamics in the cardiovascular system had attracted attention. Circulation system is a kind of "complex system" having many feedback circuits. So, it was very difficult to investigate the origin of chaos in the circulatory system. In this study, we investigated the origin of chaos by the use of the methodology of the open loop analysis with an artificial heart, which did not have any fluctuation in their own pumping rate and contraction power, in the chronic animal experiments using healthy adult goats. As a result, in the circulatory time series data of the artificial heart, which did not have any fluctuation, low dimensional deterministic chaos was discovered by the methodology of nonlinear mathematical analyzing technique, suggesting the importance of the blood vessel system in the chaotic dynamics of the cardiovascular system. To investigate the origin of chaos furthermore, sympathetic nerve activity was directly measured in the animal experiments with artificial heart circulation. Chaotic dynamics was also recognized in the sympathetic nerve action potentials, even during artificial heart circulation, suggesting the importance of a central nervous system. In the next step, in order to generate the chaotic dynamics in circulation, electrical simulation model of a left heart circulation with a feed back loop with some delay were tested and we found that we can make chaos in circulation by the feedback loop. Thus, we had constitute the artificial baroreflex system with an artificial heart system and found that we can make chaos in animal model. And finally we proposed the clinical application of these methodology for the diagnosis of an autonomic nervous system and found that it may be useful. These findings may be useful for analyzing the nonlinear dynamics in circulation.]
  • Clinical application of the origin of chaos - [Results of the foregoing paragraph showed that chaotic dynamics in circulation may be generated from the peripheral vascular properties mediated by the sympathetic discharges. If we consider the clinical application of these results, autonomic function mediating cardiovascular function may be the suitable target. In the patients with Diabetes Mellitus or Patients with myocardial ischemia showed cardiac denervation. It is an important problem for these patients. In the clinics, we used heart rate variability to analyze the autonomic function, however, there are some problems.][Results of the foregoing paragraph showed that chaotic dynamics in circulation may be generated from the peripheral vascular properties mediated by the sympathetic discharges. If we consider the clinical application of these results, autonomic function mediating cardiovascular function may be the suitable target. In the patients with Diabetes Mellitus or Patients with myocardial ischemia showed cardiac denervation. It is an important problem for these patients. In the clinics, we used heart rate variability to analyze the autonomic function, however, there are some problems.]
  • Making of the feedback loop in circulation by an artificial heart system - [It may be needless if doesn't think about QOL. A patient who implanted artificial heart will must return to the Society in future. Various kinds of stimulation from external is given to a patient after having returned to the Society. Artificial heart must respond to this condition. Even if Homeostasis is disturbed by various stimulation, it must be returned. If these requirements isn't filled, circulation can't be maintained, and of course homeostasis cannot be able to be maintained. Accordingly, stimulation from external needs to be responded. Thus, some sensor is necessary to respond to turbulence of circulation. A representative of turbulence of circulation is the alteration of a blood pressure. If blood pressure can't be maintained, circulation can't be maintained. There is arterial blood pressure reflex mechanism to maintain blood pressure in the circulatory regulatory system in the biological system. This system is considered to become necessary to maintain blood pressure in an artificial heart circulation.](matched in title)
  • Making of chaos - [However, is it really make complex system like circulatory regulatory system in creatures ?][We could constitute the feedback loop for an artificial heart automatic control algorithm by the use of an autonomic nerve discharges or Mayer wave in peripheral vascular resistances, and or so. It may be make a complicated structures in time series data as メcomplex systemモ like chaos or fractal.]
  • Sympathetic nerve discharges during artificial heart circulation - [Tohoku University has been involved continuously in AH research for over 20 years, and has developed an automatic AH control system using various types of microsensors. However, the control algorithm of the AH using hemodynamic parameters and hormonal factors could not avoid the possibility of a time delay compared with the natural heart.](matched in title)
  • Nonlinear dynamics of an artificial baroreflex system. - [In this experiments, TAH automatic control algorithm were based upon these concept. Firstly, optimal drive point of the inner sac were maintained by the automatic control algorithm for the pneumatic driver. It was needed to prevent the thrombus formation in the inner sac. Secondary, by the alteration of the stroke volume, left and right flow balances were maintained. Stroke volume changes were maintained within an optimal operating point. And at last, maintain the hemodynamics within normal range and an automatic TAH control algorithm based upon artificial baroreflex concept were added to these basic control algorithm. The TAH drive parameters used in the experiments were: pulse rate, drive air pressure, and systolic-diastolic rate. The L-R balance was controlled by dynamic balancing of blood volumes between the pulmonary and systolic circulations.][After resection of the natural heart under extracorporeal circulation, pneumatically driven sac type blood pumps were connected and set outside the body on the chest wall in chronic animal experiments using two adult female goats weighing 48 kg and 60 kg. The only medication used in these experiments was antibiotics to avoid infection. Pump output was measured at the outlet port of the left pump with an electromagnetic flowmeter. Aortic pressure, and left and right atrial pressure were measured with pressure transducers through the side tube of the cannulae. These data were fed through an A/D converter into a personal computer in which the control logic was run.]
  • Open loop analysis by the use of an artificial heart - [In order to develop an optimal automatic control algorithm of an artificial heart system for the creatures, investigation of the basic characteristics of the cardiovascular system may be important. The clinical significance of the chaotic dynamics had attracted attention, especially in the cardiovascular system, which had nonlinear dynamic behaviors [1,2]. Circulation system is a kind of "complex system" having many feedback circuits, so, it was very difficult to investigate the origin of chaos in the circulatory system.](matched in title)
  • Future planning - [!!! Development of ultra small VFP for organ blood supply][Conferences for Assisted Circulation and Artificial Heart in Shiroishi-Zao Janually]
  • Research of an autonomic nervous system - [department of medical engineering and cardiology, Institute of development, aging and cancer, Tohoku University.][* [[Artificial heart and an autonomic nervous system|http://mec1.idac.tohoku.ac.jp/AH+AN6.html]]]
  • Vagal nerve activity and information processing - [For the Quality of life (QOL) of the patients with the artificial heart system, monitoring of an information of the cardiovascular control system may be important. We’ve been evaluating an autonomic nervous system for that purpose, and recently fluctuations in hemodynamic parameters including heart rate variability (HRV) were evaluated by the use of spectral analysis and nonlinear mathematical analysis. Respiratory wave in HRV were thoght to be reflect ongoing information of the parasympathetic nerve activity. Is it true ? In order to confirm this hypothesis, we recorded vagal nerve activity directly in chronic cnimal experiments. Six healthy adult goats were anesthetized with Halothene inhalation and thoracotomy were performed by the fourth lib resection during mechanical ventilation. Arterial blood pressure, right and left atrial pressures were continuously monitored with the catheter insertion. Cardiac output were measured by the electromagnetic flowmeter attached to the ascending aorta. After the chest was closed, incision were made to the left neck and left vagal nerve were separated. Stainless steel electrodes were inserted into the vagal nerve and fixed by the plasticizer. After an incision was closed, the goats were transferred to the cage and extubated after waking. Hemodynamic parameters and vagal nerve activity were measured in the awake condition. The results showed that clear observation of the autonomic nerve discharges were embodied by this experimental system. The vagal nerve discharges were synchronized with heart beat and respiration. And tonus of the vagal nerve were significantly influenced by the hemodynamic alteration. However, respiratory wave did not always accord with tonus of the vagal nerve activity in some condition, suggesting that we must check another information to evaluate the parasympathetic tone. We must continue this study to evaluate an tunonomic nervous system during artificial heart circulation.][For the Quality of life (QOL) of the patients with the artificial heart system, monitoring of an information of the cardiovascular control system may be important. We’ve been evaluating an autonomic nervous system for that purpose, and recently fluctuations in hemodynamic parameters including heart rate variability (HRV) were evaluated by the use of spectral analysis and nonlinear mathematical analysis. Respiratory wave in HRV were thoght to be reflect ongoing information of the parasympathetic nerve activity. Is it true ? In order to confirm this hypothesis, we recorded vagal nerve activity directly in chronic cnimal experiments. Six healthy adult goats were anesthetized with Halothene inhalation and thoracotomy were performed by the fourth lib resection during mechanical ventilation. Arterial blood pressure, right and left atrial pressures were continuously monitored with the catheter insertion. Cardiac output were measured by the electromagnetic flowmeter attached to the ascending aorta. After the chest was closed, incision were made to the left neck and left vagal nerve were separated. Stainless steel electrodes were inserted into the vagal nerve and fixed by the plasticizer. After an incision was closed, the goats were transferred to the cage and extubated after waking. Hemodynamic parameters and vagal nerve activity were measured in the awake condition. The results showed that clear observation of the autonomic nerve discharges were embodied by this experimental system. The vagal nerve discharges were synchronized with heart beat and respiration. And tonus of the vagal nerve were significantly influenced by the hemodynamic alteration. However, respiratory wave did not always accord with tonus of the vagal nerve activity in some condition, suggesting that we must check another information to evaluate the parasympathetic tone. We must continue this study to evaluate an tunonomic nervous system during artificial heart circulation.]
  • References PWV - [# Asmar RG, London GM, O'Rourke ME, Mallion JM, Romero R, Rahn KH, Trimarco B, Fitzgerald D, Hedner T, Duprez D, De Leeuw PW, Sever P, Battegay E, Hitzenberger G, de Luca N, Polonia P, Benetos A, Chastang C, Ollivier JP, Safar ME. ,Amelioration of arterial properties with a perindopril-indapamide very-low-dose combination.,J Hypertens Suppl. 2001 Nov;19 Suppl # S15-20.,][# Kumaran K, Fall CH, Martyn CN, Vijayakumar M, Stein CE, Shier R. ,Left ventricular mass and arterial compliance: relation to coronary heart disease and its risk factors in South Indian adults.,Int J Cardiol. 2002 Apr;83(1):1-9.,]
  • Artificial Organs Research - [In Tohoku University, various artificial organs have been under development.][* [[Pneumatic driven Total Artificial Heart]]]
  • Pneumatic driven Total Artificial Heart - [With silastic ball valve, superior endurance may be achieved. This TAH is now in the stage of fitting study to the goat's chest cavity.](matched in title)
  • eng_top - [Department of medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University][Artificial Heart Research Program in Tohoku Univ. were performed in this department. Deterministic chaos & fractal theory concerning medical field were also studied in this department, especially in the field of Cardiology. Clinical studies of the interventional therapy and ultrasonic cardiology were performed in the various hospitals in this prefecture.]
  • The Institute of Development, Aging and Cancer, Tohoku University and the Smolensk State medical academy concluded the scientific agreement. - (matched in title)[The rate for which the cardiovascular event in the total death accounts exceeds 59%, and the most is an ischemic heart disease.]
  • PDE阻害薬の強心作用とEmaxのカオス的ダイナミクス - [# Maskin CS, Sinoway L, Chadwick B, Sonnenblick EH, Le Jemtel TH. Sustained hemodynamic and clinical effects of a new cardiotonic agent, WIN 47203, in patients with severe congestive heart failure. Circulation. 1983 May;67(5):1065-70.][# Suga H, Sagawa K, Shoukas AA: Load independence of the instantaneous pressure-volume ratio of the canine left ventricle and effects of epinephrine and heart rate on the ratio. Circ Res. 1973 Mar;32(3):314-22.]
  • 論文・出版リスト - 西條先生分 - [# Saijo Y, Nitta S, Kobayashi K, Arai H, Nemoto Y. Development of an ultra-portable echo device connected to USB port. Ultrasonics, Vol. 42, No. 1-9, 699-703, 2004.][# Saijo Y, Sasaki H, Naganuma T, Tanaka M. Assessment of three-layered appearance of coronary artery in intravascular ultrasound by scanning acoustic microscope. Eur Heart J. Vol. 15, suppl; 258, 1994.]
  • ロータリーポンプEvaHeart動物実験 - [補助人工心臓は本来、心臓に悪い方に埋め込まれるのわけですから、補助心臓で全身の循環を維持していても不幸にして致死的な不整脈を合併してしまう患者様も散見されます。 そこで東北大学では[[心停止下における補助循環の実験|http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1551728&query_hl=1]]を行ってきました。空気圧駆動型の補助人工心臓では、心停止状態でもある程度は左心補助人工心臓のみで循環が維持できることなどを研究してきました。 現在は、国産の超小型ロータリーポンプとして注目されエバハートなどを用いて、例え心停止状態においても左心室の補助循環のみで全身の循環が維持できないか研究を進めています。](matched in title)
27 page(s) containing the phrase 'Eve', 'heart' were found in a set of 269 pages.
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